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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390
It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.
Leaching toxicity characteristics of municipal solid waste incineration bottom ash
Khamphe PHOUNGTHONG,Yi XIA,Hua ZHANG,Liming SHAO,Pinjing HE
《环境科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 399-411 doi: 10.1007/s11783-015-0819-5
关键词: Municipal solid waste incineration bottom ash alternative material leaching tests toxicity Vibrio qinghaiensis (Q67)
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
《农业科学与工程前沿(英文)》 页码 110-119 doi: 10.15302/J-FASE-2021390
关键词: antiviral plant protectant antiviral in the greenhouse field evaluation L-trp-NCA synthesis optimization toxicity tests
Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 82-89 doi: 10.1007/s11684-015-0376-0
Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6–15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6–20 pregnant days were significantly different (P<0.01, P<0.05). Significant dose related adverse effects to other reproductive parameters were not seen in F0 and F1, but the number of stillbirths in high dose group showed notably difference compared with the control group (P<0.05), while the litter incidence showed no difference. No Metacavir-associated pathological changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.
关键词: deoxyguanosine analogue Metacavir pregnancy maternal toxicity embryo toxicity teratogenicity
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1571-2
● Adsorption of PFASs on MPs and its mechanisms are critically reviewed.
关键词: Microplastics Per- and Polyfluoroalkyl substances Adsorption Transport Transformation
《环境科学与工程前沿(英文)》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1501-8
• Oxidation of methotrexate by high-valent metal-oxo species was first explored.
关键词: Anticancer drugs High-valent metal-oxo species Oxidation kinetics Reaction mechanisms Multi-endpoint toxicity
Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse
Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 89-98 doi: 10.1007/s11783-013-0591-3
关键词: waste foundry sand toxicity bioassay soil microbial activity waste reuse
《环境科学与工程前沿(英文)》 2022年 第16卷 第5期 doi: 10.1007/s11783-021-1493-4
• A two-compartment model is able to quantify the effect of nano-TiO2 on Pb toxicity.
关键词: Algae C. dubia Lead Nano-TiO2 Synergistic toxicity Two-compartment toxicokinetic-toxicodynamic model
Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”
Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg
《环境科学与工程前沿(英文)》 2017年 第11卷 第2期 doi: 10.1007/s11783-017-0916-8
关键词: Metal Mixtures Toxicity Additivity Modeling Interactions
Toxicity-oriented water quality engineering
Shengkun Dong, Chenyue Yin, Xiaohong Chen
《环境科学与工程前沿(英文)》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1259-4
Assessment of toxicity of two nitroaromatic compounds in the freshwater fish
Hongyan SHEN, Jixi GAO, Jinsheng WANG
《环境科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 518-523 doi: 10.1007/s11783-012-0427-6
关键词:
joint toxicity
Study of base friction simulation tests based on a complicated engineered bridge slope
Liu HE, Guang WU, Hua WANG
《结构与土木工程前沿(英文)》 2012年 第6卷 第4期 页码 393-397 doi: 10.1007/s11709-012-0174-6
关键词: base friction test slope stability evaluation bridge slope
Strain localization analyses of idealized sands in biaxial tests by distinct element method
Mingjing JIANG, Hehua ZHU, Xiumei LI,
《结构与土木工程前沿(英文)》 2010年 第4卷 第2期 页码 208-222 doi: 10.1007/s11709-010-0025-2
关键词: idealized sand strain localization numerical analyses distinct element method (DEM)
Ismael Matino, Valentina Colla, Teresa A. Branca
《化学科学与工程前沿(英文)》 2018年 第12卷 第4期 页码 718-730 doi: 10.1007/s11705-018-1771-2
For improving wastewater quality, one of the dare of steelworks is reducing cyanide in wastewater of gas washing treatment of blast furnaces. Costs of existing treatments, stringent environmental regulations and changeable composition of water from gas treatment, have led to study how available treatments can be modified and to examine new ones. Ozonation is one of cyanide treatments, tested within a European project. A process model was set up with Aspen Plus®, to assess operating conditions and wastewater distinctive characteristics and to demonstrate treatment robustness. Process was modeled by theoretical reactors, taking into account all more affecting reactions. A genetic algorithm was exploited to find kinetic parameters of these reactions. After validation, the model was used to analyse scenarios, by considering also real contexts. Pilot tests were extended, process knowledge was enhanced and suggestions were obtained. To promote cyanide removal with ozone, temperature and pH values were 30°C and 10, respectively. With an ozone (mg/h)/water (L/h) ratio of 100 mg/L, batch mode ensure reaching cyanide regulation limit (0.2 mg/L) after maximum 4.5 h, if initial amount was less than 20 mg/L. Higher removal was obtained than in continuous mode due to constraints related to this last run. Higher wastewater contamination needed further time and more ozone.
关键词: blast furnace cyanide removal gas washing water modeling and simulation ozonation
Predictive models on photolysis and photoinduced toxicity of persistent organic chemicals
Qing ZHANG
《环境科学与工程前沿(英文)》 2013年 第7卷 第6期 页码 803-814 doi: 10.1007/s11783-013-0547-7
关键词: quantitative structure-activity relationship (QSAR) models photodegradation persistent organic pollutants environmental media mechanisms
标题 作者 时间 类型 操作
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
期刊论文
Leaching toxicity characteristics of municipal solid waste incineration bottom ash
Khamphe PHOUNGTHONG,Yi XIA,Hua ZHANG,Liming SHAO,Pinjing HE
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
期刊论文
Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats
null
期刊论文
Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic
期刊论文
Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate
期刊论文
Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse
Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG
期刊论文
Understanding the role of nano-TiO on the toxicity of Pb on through modeling–Is it additive or synergistic
期刊论文
Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”
Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg
期刊论文
Assessment of toxicity of two nitroaromatic compounds in the freshwater fish
Hongyan SHEN, Jixi GAO, Jinsheng WANG
期刊论文
Study of base friction simulation tests based on a complicated engineered bridge slope
Liu HE, Guang WU, Hua WANG
期刊论文
Strain localization analyses of idealized sands in biaxial tests by distinct element method
Mingjing JIANG, Hehua ZHU, Xiumei LI,
期刊论文
Extension of pilot tests of cyanide elimination by ozone from blast furnace gas washing water through
Ismael Matino, Valentina Colla, Teresa A. Branca
期刊论文